THE EFFECTS OF CLONIDINE ON MEMBRANE PROPERTIES OF THE NEURONS OF GUINEA-PIG CELIAC GANGLIA
- VernacularTitle:可乐定对豚鼠腹腔神经节细胞膜特性的作用
- Author:
Ruchun MA
;
Ruiling WU
;
Yijian DONG
- Publication Type:Journal Article
- Keywords:
clonidine;
sympathetic ganglion, guinea-pig
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
This work was carried out to investigate the effects of clonidine on some electrophysiological properties of the neurons of guinea-pig celiac ganglia in vitro, using the technique of intracellula.r recording. 54 neurons were examined, among which 18 neurons were found to be sensitive to clonidine. There were 3 reaction types in the sensitive cells, depolarization with decrease of membrane resistance, hyperpolarization with increase of membrane resistance and biphasic reaction ( depolarization followed by hyperpolarization ) . Clonidine depolarization was not blocked by low Ca^/high Mg2+ solution, pro-pranolol and yohimbine. However, it was reversibly blocked by prazo-sin. The experimental results show that clonidine has some! effects on the membrane potential and membrane resistance of the neurons of guinea-pig celiac ganglia,
