THE EFFECT OF GOSSYPOL ON K~+, Na~+ AND TESTOSTERONE IN SERUM AND RAT TESTIS FLUID IN RATS
- VernacularTitle:醋酸棉酚对大鼠睾网液中K~+、Na~+及睾酮水平的影响
- Author:
Jiansun TONG
;
Aiping QI
;
Ru WANG
;
Jianjun MA
;
Shaozhen QIAN
- Publication Type:Journal Article
- Keywords:
acetic gossypol, RTF ( rete testis fluid);
K+, Na+;
testosterone
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Feeding adult male rats with gossypol acetic acid at a dose of 15 nig/kg/day for 50 days led to infertility. Spermatogenesis and sperm motility were impaired ( table 1 ) . However, testosterone, K+ and Na+ concentsrations in serum and RTF were found to be unchanged (table 2, 3 ) . It suggests that at low antifertility doses gossypol disrupts spermatogenesis in the seminiferous epithelium without affecting testosterone, K+ and Na+ secretion and translation in testis.
