Protective effect of glucocorticoid preconditioning on the myocardial ischemic and reperfused rabbit heart
- VernacularTitle:糖皮质激素预处理对兔心肌缺血再灌注损伤的保护作用
- Author:
Shengru WANG
;
Shaoli CHENG
;
Rong GUO
;
Jian LIU
;
Ling LI
;
Mingyong WANG
;
Jie XU
;
Jun RUI
;
Lixiong QIAN
;
Ke GAO
- Publication Type:Journal Article
- Keywords:
glucocorticoid;
cardiac muscle;
ischemica reperfusion injury;
rabbit
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
1981;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the protective effect of glucocorticoid preconditioning on the myocardial ischemic and reperfused hearts.Methods Totally 18 rabbits were randomly divided into three groups: myocardial ischemia-reperfusion model(model),high-dose glucocorticoid given by one time group(high-dose group) and low-dose glucocorticoid given by several times group(low-dose group),with six rabbits in each group.Myocardial ischemia was induced by left anterior descending coronary artery ligation.ST segments were recorded by the BL-420 biological signal acquisition system.Plasma malondial dehyde(MDA) was examined before ischemia,at 15 min after ischemia and 30 min after reperfusion;ischemic heart muscles were prepared with cryotomy and stained histochemically.Succinic dehydrogenase activity was observed in the ischemic region.Results There was shorter time of ST-segment recovery in the high-dose group and the low-dose group than that in the model group.Serum level of MDA in the high-dose group was lower than in the low-dose group(P
