Preparation of Paracetamol multiloculated implant and its drug release profile in vitro
- VernacularTitle:扑热息痛多腔体贮库式植入剂的制备及体外释放性能检测
- Author:
Weifeng LI
;
Xiaopeng WANG
;
Xiaofeng NIU
;
Yanling LIU
;
Te FAN
- Publication Type:Journal Article
- Keywords:
Paracetamol;
poly-lactide-co-glycolide acid;
multiloculated implant;
in vitro release
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2003;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To prepare Paracetamol (APP) multiloculated implant loaded with poly-lactide-co-glycolide acid (PLGA) and to study the drug release profile in vitro. Methods APP multiloculated implant was fabricated by micro-electro-mechanical system (MEMS), and high-performance liquid chromato graphy (HPLC) measurement was used to investigate in vitro drug release profile. HPLC analysis was carried out by employing C18 column and a mixture of methanol-water (15∶85) as mobile phase. The detection wavelength was 215nm and flow rate was 0.8mL/min. Results With different multiloculated shape, the rate of the drug release in vitro was varied significantly. Moreover, the releasing of APP multiloculated implant with ecto-tetragonum ento-hexagon in vitro conformed to Higuchi equation. Conclusion The technology of the preparations is feasible, and the structural and morphological characteristics of the multiloculated implant have a significant impact on the release speed of the drug delivery system.
