SYNERGISTIC EFFECT OF HYPERTHERMIA ON PHOTOCARCINORIN PHOTODYNAMlC THERAPY
- VernacularTitle:再探高温效应在光敏疗法中的协同作用
- Author:
Rongchun DONG
- Publication Type:Journal Article
- Keywords:
photochemotherapy;
synergistic effect of hyperthermia;
SMMC-7721 human hepatoma cell line;
photocarcinorin
- From:
Academic Journal of Second Military Medical University
1985;0(05):-
- CountryChina
- Language:Chinese
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Abstract:
In this paper, we describe a synergistic effect of hyperthermia on photocarcino-rin photodynamic therapy. The results suggest that the synergistic action of hyperthermia and photodynamic reaction was markedy better than that of hyperthermia alone plus photocarcinorin alone. with hyperthermia treatment (42℃, 30 min) alone, the fraction of cells inactivated was 7%, while with photodynamic effect alone(1J/cm2) that was 30% (?5%).when the same dosage of irradiation was applied after a rise in temperature, the fraction of cells inactivated increased to 80% (?5%) and when temperature was raised to the same amount after irradiation the fraction of cells inactivated increased to 92%. It can be seen that hyperthermia enhances, the response of tumor cells to photocarcinorin photodynamic effect in a synergistic way.
