PDTC suppresses cholesterol induced C-reactive protein expression in L-02 cell line
- VernacularTitle:吡咯烷二硫代氨基甲酸盐抑制胆固醇诱导的人肝细胞C反应蛋白的表达
- Author:
Junli TANG
;
Haiyan XU
;
Xiping LIU
;
Minzhang QIAN
- Publication Type:Journal Article
- Keywords:
C reactive protein;
cholesterol;
atherosclerosis;
nuclear factor kappa B(NF-?B)
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
1981;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of PDTC on cholesterol induced C-reactive protein gene expression in L-02 cell line.Methods Human hepatocyte cell line L-02 was cultured in vitro;growth-arrested cells were divided into 3 groups,cholesterol group,PDTC+cholesterol group and control group.After 48 h incubation,western blot and immunoturbidimetry assays were carried out to detect intracellular and secreted C reactive protein expression.Results Cholesterol stimulated CRP gene expression in L-02(P
