Study on the Energy Metabolism of Skeletal Muscle of Healthy People in Different Age Group using Phosphorus MR Spectroscopy
- VernacularTitle:磁共振磷谱(~(31)P-MRS)探测不同年龄正常人骨骼肌能量代谢的特点
- Author:
Jing QI
;
Dehang WANG
;
Xiaomei ZHU
- Publication Type:Journal Article
- Keywords:
phosphorus MR spectroscopy;
skeletal muscle;
energy metabolism
- From:
Journal of Practical Radiology
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the energy metabolism of normal muscle in different age group.Methods Noninvasive 31P-MRS was acquired from quadriceps muscles in healthy people including 10 adults and 6 juvenile.Peak areas were standardized for longitudinal saturation and coil inhomogeneity.The concentration of phosphomonoesterase(PME),inorganic phosphate(Pi),phosphodiesterase(PDE),phosphocreatine(CrP)and adenosine triphosphate(ATP)was determined from spectra.Concentrations of adenosine diphosphate(ADP)and phosphorylation potential(PP)were calculated from the biochemistry reaction equilibrium.Enzymatically active magnesium ATP complex Mg-ATP and pH value were determined from relative chemical shift.Results Normal muscle had prominent high energy phosphate peaks,the mean concentration of CP and ATP was 24.76 and 18.38 mmol/kg in adults,25.52 and 21.36 mmol/kg in young subject.In comparison with adult group,young subjects had lower PDE and higher ATP values.pH value,magnesium ATP and total magnesium were higher in young subjects too.Pi,CP,ADP,PP,free Mg2+ and free ATP concentration were similar in both group.Conclusion High energy compounds were slightly higher in juvenile subjects.31P-MRS is a noninvasive technique to evaluate energy metabolism in different age group.
