Characteristics of the peripheral blood CD45RA~+ and CD45RO~+ T lymphocyte subsets in the patients with chronic hepatitis B and its clinical significance
- VernacularTitle:慢性乙型肝炎患者外周血CD45RA~+、CD45RO~+ T淋巴细胞亚群的特点及临床意义
- Author:
Shengli BI
;
Sien ZHAN
;
Yuguo SONG
;
Jianwen HUANG
- Publication Type:Journal Article
- Keywords:
CD45RA;
CD45RO;
T lymphocyte;
Chronic hepatitis B(CHB);
Hepatitis B virus(HBV);
FCM
- From:
Chinese Journal of Immunology
1985;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To characterize the CD4+CD45RA+,CD4+CD45RO+,CD8+CD45RA+ and CD8+CD45RO+T lymphocyte subsets in the peripheral blood of the patients with chronic hepatitis B and to explore their relations with the disease state.Methods:The peripheral blood was collected from 104 patients with chronic hepatitis B and 30 healthy individuals,then CD4+CD45RA+,CD4+CD45RO+,CD8+CD45RA+ and CD8+CD45RO+T lymphocyte subsets were detected by flow cytometry with three-color fluorescence technology.Results:To compare with the control,the percent of CD8+CD45RA+T lymphocyte in patients with mild and severe grad CHB decreased markedly,the percent of CD8+CD45RO+T lymphocyte increased markedly,CD4+,CD8+,CD4+CD45RA+ and CD4+CD45RO+T lymphocyte did not change obviously. Compared with the mild grade CHB,the percent of CD8+CD45RA+T lymphocyte in patients with severe grade CHB decreased obviously(P
