Expression of c-met mRNA in The Drainage from Axillary Fossa after Operation for Breast Cancer
- VernacularTitle:c-met mRNA在乳腺癌术后腋窝引流液中表达的意义
- Author:
Weijun YANG
;
Zhigang HUANG
;
Chunlai LI
;
Zhengyang WU
;
Jiajun YIN
- Publication Type:Journal Article
- Keywords:
Breast cancer Micrometastasis RT-PCR c-met mRNA
- From:
Chinese Journal of Bases and Clinics in General Surgery
2003;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the significance of c-met mRNA in axillary drainage after operations for breast cancer. Methods RT-PCR assay was used to examine c-met mRNA in axillary drainage after operations in 52 cases of breast cancer. The relationships between the expression of c-met and the tumor size, metastatic lymph nodes, the expressions of estrogen receptor (ER), progesterone receptor (PR) and c-erbB-2 were analyzed, respectively. In addition, the effect of douching operative field with 5-FU and distilled water on the expression of c-met mRNA was also analyzed. Results ①The proto-oncogene c-met mRNA could be detected in axillary drainage after operations for breast cancer by RT-PCR, and its positive rate was higher than that in routine pathological detection for micrometastasis in the axillary lymph nodes (P
