Four Cases of Atypical Chronic Myeloid Leukemia.
- Author:
Soo Jin YOO
1
;
Su Gyoung KANG
;
Eul Ju SEO
;
Chan Jeoung PARK
;
Kyoo Hyung LEE
;
Hyun Sook CHI
Author Information
1. Department of Clinical Pathology, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea. cjpark@amc.seoul.kr
- Publication Type:Case Report
- Keywords:
Atypical chronic myeloid leukemia;
FAB guideline;
bcr-abl negative chronic myeloid leukemia
- MeSH:
Basophils;
Bone Marrow;
Classification;
Diagnosis;
Gene Rearrangement;
Humans;
Hydroxyurea;
Hyperplasia;
Leukemia, Myelogenous, Chronic, BCR-ABL Positive;
Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative*;
Leukocytosis
- From:Korean Journal of Clinical Pathology
2002;22(2):75-79
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Four cases of atypical chronic myeloid leukemia (aCML), which were compatible with the FAB guideline for the classification of chronic myeloid leukemia (CML), are presented. All 4 patients showed the onset in old age, leukocytosis with an increase in the number of immature granulo-cytes, monocytosis, a low basophil count, and a dysgranulopoiesis in the peripheral blood, a nega-tivity of the bcr-abl gene rearrangement, and a hypercellular marrow with marked granulocytic hyperplasia and dyshemopoietic features. Two patients died within 3 months and the other 2 are currently under observation after a partial response to hydroxyurea. aCML is known to have a poor therapeutic response and outcome without a blastic crisis. A greater deal of concern regarding aCML is required for an accurate diagnosis and classification.
