Relationship between DRD2 - 141C Ins/Del Polymorphism and Heroin Craving
- VernacularTitle:多巴胺D2受体-141C Ins/Del多态与海洛因渴求的关系
- Author:
Chunhong SHAO
;
Kaida JIANG
;
Yifeng LI
- Publication Type:Journal Article
- Keywords:
Heroin Dependence;
Cue;
Craving;
Dopamine D2 receptor;
Polymorphism
- From:Chinese Journal of Clinical Psychology
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the relationship between DRD2 - 141C Ins/Del polymorphism and heroin craving. Methods:380 heroin addicts who were under abstinence were given the cue- elicited heroin craving experiment. And then we detected the polymorphism of DRD2- 141CIns/Del for them by using PCR- RFLP. We compared the relationship between genotypes of DRD2- 141CIns/Del and heroin craving before and after cue exposure. Results:No significant differ- ence has been found between heroin craving before and after cue- exposure in three genotypes of DRD2- 141CIns/Del. Conclusion:D2 receptor gene - 141CIns/Del polymorphisms may have no association with the susceptibility of heroin crav- ing.
