Expression of surviving and its correlation with thymidine kinase and axillary lymph node metastasis in breast cancer
- VernacularTitle:乳腺癌survivin和TK1的表达及其与腋窝淋巴结转移的关系
- Author:
Qing GAO
;
Jianping WU
;
Yongrong MAO
;
Hai LAN
- Publication Type:Journal Article
- Keywords:
Survivin;
Thymidine kinase;
Breast neoplasm;
Metastasis
- From:
Cancer Research and Clinic
2000;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of survivin and its correlation with tumor thymidine kinase and axillary lymph node metastasis in breast cancer. Methods Expression of survivin and cytosolic thymidine kinase(TK) in 60 cases of breast cancer(28 cases with axillary lymphonode metastasis) were measured by immunohistochemistry. Results There was expression of survivin in breast cancer; labeling index(LI) of TK in breast cancer cells with positive expression of survivin was significantly higher than that with negative expression of survivin;the positive percent of survivin expression in breast cancer with axillary lymph node metastasis was higher than that without axillary lymph node metastasis. Conclusions The expression of survivin in breast cancer is related to TK and axillary lymph node metastasis.
