The expression of P-gp, GST-? and TopoⅡ in breast cancer and their clinical significance
- VernacularTitle:乳腺癌P-gp、GST-?及TopoⅡ的表达及意义
- Author:
Zaixing DENG
;
Bei XIE
;
Wenju YU
- Publication Type:Journal Article
- Keywords:
Breast neoplasm;
Multidrug resistance;
P- glycoprote;
Glutathione- S- transferase- ?;
TopoisomeraseⅡ
- From:
Cancer Research and Clinic
2000;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and their clinical significance of P?- glycoprotein (P?- gp), glutathione?- S?- transferase?- ?(GST?- ?)and DNA topoisomerase Ⅱ(TopoⅡ)in breast cancer. Methods The expressions of P?- gp, GST?- ? and TopoⅡ were detected in 60 cases of untreated primary breast cancer by using immunohistochemical S?- P method. Results The positive expression rates of P?- gp, GST?- ? and TopoⅡ in breast cancer were 37.1 %, 66.7 % and 55.0 % respectively. The expression of P?- gp and TopoⅡ had positive correlation with degree of differentiation(P
