Effects of 17? -estradiol on hydrogen peroxide-induced cell death in cultured retinal neurons
- VernacularTitle:17?-雌二醇对H_2O_2诱导视网膜神经细胞死亡的作用
- Author:
Xiaorui YU
;
Guangdao GAO
- Publication Type:Journal Article
- Keywords:
estradiol;
H 2O 2;
retina;
neuron
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
1982;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the protective effect of 17?-estradiol (?E2) on cultured retinal neurons. Methods By using methods of the cultured retinal neurons, the effects of H 2O 2, ? E2, and tamoxifen, the estrogen receptor antagonist, on the cultured retinal neurons were observed. Results H 2O 2 significantly decreased cell viability in cultured retinal neurons in a dose- and time-dependent manner. When the retinal neurons were pretreated with ? E2 30 min prior to H 2O 2 treatment, cell viability was significantly increased (P
