Study of retrograde axonal transport of ~ 125 I-Schwann cell derived neurotrophic factor by motor neurons
- VernacularTitle:许旺细胞源神经营养因子在运动神经元轴突逆行运输的研究
- Author:
Ping LI
;
Yangbin XU
;
Junchi LIU
- Publication Type:Journal Article
- Keywords:
Neurotrophic factors;
125 I;
Axonal retrograde transport;
Schwann cell;
Spinal motor neuron
- From:
Chinese Journal of Microsurgery
2000;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the retrograde axonal transport of Schwann cell derived neurotrophic factor(SDNF)by motor neurons Methods SDNF was labeled with Chloramine T, 125 I SDNF and 100 fold excess of unlabelled SDNF was injected into the right hindlegs of neonatal rats separately The spinal cords was removed for counting in a counter Results The radioactive level of experimental side was more than contralateral side The transport was blocked by 100 fold excess of unlabelled SDNF Conclusion SDNF was transported retrogradely by spinal motor neurons
