Regulation of cytokines on the expression of fibronectin in the endometrium of early pregnant mice
- VernacularTitle:细胞因子调节对纤连蛋白在孕早期小鼠子宫内膜表达的研究
- Author:
Wei ZHANG
;
Jianping ZHUO
;
Yinkun LIU
- Publication Type:Journal Article
- Keywords:
Fibronectin Leakemia inhibitory factor Interleukin-1 Embryo implantation
- From:
Chinese Journal of Immunology
2000;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the regulation mechanism of fibronectin expression by studying the fefiects of cytokines on the expression of Fn in the endometrium of early pregnant mouse. Methods: The early pregnant mice were injected with cytokines, such as interlukin-l.inter-lukin-1ra, leukemia inhibitory factor, at different concentration.The levels of Fn protein and mRNA in endometrium were measured by immunob-lot and RT-PCR method.Results: Fn protein and mRNA level of LIF groups, other low or high concentration, were higher than that of control group( P
