Advances in research on relation of ubiquitin-proteasome pathway to malignancy
- VernacularTitle:泛素-蛋白酶体途径与恶性肿瘤关系的研究进展
- Author:
Jianjun XIE
;
Yamei HU
;
Youyong LU
- Publication Type:Journal Article
- Keywords:
ubiquitin;
proteasome;
malignancy
- From:
China Oncology
1998;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Ubiquitin-proteasome pathway is an important mechanism regulating many processes of cellular biology,and also a potential target for abnormal regulation associated with malignancy. This pathway may up-regulate or down-regulate the expression of some tumor-inhibitory genes, transcriptional factors and cyclins,and alter the generation of MHC-I-restricting antigen peptides through the activity of specific proteasome, and consequently,participates in the genesis and progression of malignancy.
