The association of cytotoxic T lymphocyte-associated antigen 4 gene polymorphism with type 1 diabetes mellitus and autoimmune thyroid diseases in Chinese Han population
- VernacularTitle:细胞毒性T淋巴细胞相关抗原4基因多态性与中国汉族人1型糖尿病、自身免疫性甲状腺病的相关性研究
- Author:
Luan WANG
;
Hongwei YU
;
Shenli YAN
- Publication Type:Journal Article
- Keywords:
Polymorphism (Genetics);
Diabetes mellitus, insulin dependent;
Autoimmune thyroid diseases;
Cytotoxic T lymphocyte associated antigen 4 gene
- From:
Chinese Journal of Endocrinology and Metabolism
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association of cytotoxic T lymphocyte associated antigen 4 (CTLA 4) gene polymorphism with type 1diabetesmellitusandautoimmunethyroiddiseases. Methods The A/G phenotype at position 49 of the CTLA 4 gene exon 1 was determined by PCR RFLP method in 33 classic type 1 diabetes patients, 57 latent autoimmune diabetes in adults (LADA) patients, 122 autoimmune thyroid disease patients and 84 healthy control subjects of Chinese Han. Results The frequency of the CTLA 4 G phenotype was significantly higherintype1diabetespatientsthanthatincontrol subjects (55.6% vs 36.9%, P=0.0005). Neither the presence nor the absence of G allele influenced the occurrence of islet autoantibody (ICA) and glutamate decarboxylase antibody (GADA). The strong association of the CTLA 4 G allele with AITDs was showed in our study (66.4% vs 36.9%, P
