Effect of extract of Oratosquilla oratoria on telomerase activity in human nasopharyngeal carcinoma cell line
- VernacularTitle:口虾蛄提取物对人鼻咽癌细胞端粒酶活性的影响
- Author:
Xia KONG
;
Dishui GU
;
Mingyong LI
;
Jin CHEN
;
Peichun HUANG
- Publication Type:Journal Article
- Keywords:
Oratosquilla oratoria;
Nasopharyngeal neoplasms;
Telomerase
- From:
Chinese Journal of Pathophysiology
1989;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To study the inhibitory effect and its mechanisms of the extract of Oratosquilla oratoria (EOS) on the activity of telomerase in human nasopharyngeal carcinoma cell line CNE-2Z. METHODS:MTT assay was used to determine the effect of different doses of EOS on the proliferation of CNE -2Z cells. The activity of telomerase was analyzed by TRAP-ELISA. The mRNA expression of hTERT was determined by RT-PCR,and the protein expression of c-Myc was detected by Western blotting. RESULTS:EOS inhibited the proliferation of CNE-2Z cells in a dose-dependent manner (P
