Anesthetic Effect of Isoflurane and Sevoflurane in Mice with Oral Administration
- VernacularTitle:口服异氟烷、七氟烷对小鼠的麻醉作用观察
- Author:
Xiaolin XU
;
Yinbao CHEN
;
Suyang QI
;
Hui WANG
;
Chunlei SHI
;
Jue WANG
;
Bin SHEN
;
Tijun DAI
;
Lichun XU
- Publication Type:Journal Article
- Keywords:
Isoflurane;
Sevoflurane;
Mice;
Hypnosis;
Analgesis;
Oral administration;
Anesthetic effect
- From:
China Pharmacy
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the analgesic and hypnotic effects of oral isoflurane(Iso)and sevoflurane(Sev). METHODS:180 mice were randomly divided into 18 groups(n=10). It included in hot-plate test(n=60),writhing test(n= 60),i.e. NS group,Iso1 group(1 mL?kg-1),Iso2 group(2 mL?kg-1),Iso3 group(3 mL?kg-1),Sev1 group(5 mL?kg-1),Sev2 group(10 mL?kg-1). Another six groups were included in sleeping test,i.e. NS group,Iso1 group(6 mL?kg-1),Iso2 group(8 mL?kg-1),Iso3 group(10 mL?kg-1),Sev1 group(20 mL?kg-1),Sev2 group(40 mL?kg-1). Hot-plate test,writhing test,sleeping test were employed to evaluate the hot- plate pain threshold(HPPT),writhing times(WT)and sleeping time(ST)respectively after i.g. administration of Iso and Sev to evaluate analgesic and hypnosis effect. RESULTS:As compared with NS group,Iso(1～3 mL?kg-1)and Sev(5,10 mL?kg-1)with intragastric administration could increase the HPPT and decrease the WT(P
