Formulation Design and Content Determination of Thermosensitive Secnidazole Hydrogels
- VernacularTitle:塞克硝唑温敏性水凝胶的处方设计与含量测定
- Author:
Xianling SHEN
- Publication Type:Journal Article
- Keywords:
Secnidazole;
Thermosenstive hydrogels;
Orthogonal design;
Poloxamer;
Content determination
- From:
China Pharmacy
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To select the optimal formulation of thermosensitive secnidazole hydrogels and establish its determination method. METHODS:Formulation was optimized by orthogonal design with the content of poloxamer P407/P188(A),ethanol (B)and sodium alginate(C)as factors and with secnidazole as index. The content of secnidazole in preparation was determined by UV spectrometry at detection wavelength of 277 nm. RESULTS:The optimal formulation was as follows:A of 15 g/15 g,B of 20 mL and C of 0.6 g. The linear range of secnidazole was 4.618～46.18 mg?L-(1r=0.999 8)with an average recovery of 98.27%. The RSD of intra-day and inter-day were both lower than 1.8% and 2.1% respectively. CONCLUSIONS:The formulation is reasonable and the process was reliable and controllable in quality.
