Influence of Reduced Glutathione on Serum Liver Fibrosis Index and Cytokines in Patients with Chronic Hepatitis B
- VernacularTitle:还原型谷胱甘肽对慢性乙型肝炎患者血清肝纤维化指标和细胞因子的影响
- Author:
Xinwen SONG
;
Baosheng SHEN
;
Hongwei WANG
;
Haili GAO
- Publication Type:Journal Article
- Keywords:
Reduced glutathione;
Chronic hepatitis B;
Liver fibrosis
- From:
China Pharmacy
1991;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the influence of reduced glutathione(GSH) on serum liver fibrosis index and cytokines in patients with chronic hepatitis B(CHB) . METHODS:96 patients with CHB were randomly divided into the treatment group(treated with GSH) and control group. The serum levels of TGF-?1,TNF-?,hyaline acid(HA) ,type Ⅳcollagen(C-Ⅳ) ,laminin(LN) ,Alanine aminotransferase(ALT) and Aspartate Aminotransferase(AST) were measured by specific-ELISA and RIA assay before and after treatment. Healthy group made up of 30 healthy volunteers. RESULTS:Before treatment the serum levels of ALT,AST,TGF-?1,TNF-?,HA,C-Ⅳ and LN in CHB group were significantly increased,as compared with heatthy group(P
