Effects of Different Concentration of Human Urinary Kallikrein on Blood Pressure in the Treatment of Acute Cerebral Infarction
- VernacularTitle:不同浓度人尿激肽原酶治疗急性脑梗死对患者血压的影响研究
- Author:
Liang FENG
;
Zhao HAN
;
Chengye ZHOU
;
Ying ZHANG
- Publication Type:Journal Article
- Keywords:
Human urinary kallikrein;
Cerebral infarction;
Blood pressure;
Angiotensin-converting enzyme inhibitor
- From:
China Pharmacy
2005;0(17):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the effects of different concentration of human urinary kallikrein on blood pressure when used for acute cerebral infarction. METHODS: By a non-randomized historical control study,the blood pressure variation of 34 patients on day one after treatment with low concentration (0.06%) of human urinary kallikrein was observed,the occurrence of hypotension in this group was compared with that of another 47 patients (control) treated with high concentration (0.3%) of human urinary kallikrein. RESULTS: The reduction of blood pressure in low concentration group was less obvious than in the high-concentration group. However,hypotension was noted in both groups when angiotensin-converting enzyme inhibitor (ACEI) hypotensive drugs were used concomitantly. CONCLUSION: Human urinary kallikrein for acute cerebral infarction can transiently down-regulate blood pressure slightly,but its effect on blood pressure can be lowered by suitable reduction of its concentration;at any concentration,it can result in hypotension if used in combination with ACEI.
