Role and characteristic of Bmi-1 in the nervous development and tumorigenesis
- VernacularTitle:Bmi-1在神经系统发育和肿瘤发生中的作用和特点
- Author:
Yuanpeng XIA
;
Bo HU
- Publication Type:Journal Article
- Keywords:
Genes,Bmi-1;
Neural stem cells;
Neural development;
Neural neoplasms
- From:
Chinese Journal of Pathophysiology
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Polycomb group proteins Bmi-1 is the core subunits of the PRC1 complex,and also plays important roles in the regulation of neural development. This review introduces the construction of Bmi-1 and the recent study for Bmi-1 in the nervous system development and tumor generation. The important roles of Bmi-1 for sustain of the neural stem cell proliferation,regulation mechanism of neural development and tumor generation are discussed.
