Advances in the study on FAK-ERK and its applicable value in forensic medicine
- VernacularTitle:FAK-ERK的研究进展及其法医学应用价值
- Author:
Tianshui YU
;
Dawei GUAN
;
Zihui CHENG
- Publication Type:Journal Article
- Keywords:
Forensic pathology;
Focal adhesion kinase;
Extracellular signal-regulated protein kinase;
Wound
- From:
Chinese Journal of Forensic Medicine
2002;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Focal adhesion kinase(FAK)and extracellular signal-regulated protein kinase(ERK),which are thought to play major roles in transducing surface receptor-derived signals into nucleus,are pivotal signal transduction molecules in mammalian cells.FAK is activated through phosphorylation by extracellular stimuli.p-FAK activates the downstream of ERK which changes cell action.FAK-ERK signal conduction factors are involved in a variety of biological responses,such as cell proliferation,differentiation,stress,apoptosis and malignant change.The biologic characters of FAK-ERK and advances in the study on its roles in tissue damage are reviewed in this article,which may provide a more effective way for estimation of wound age in forensic medicine.
