Changes of hemodynamic parameters and ECG in circulatory failure rats induced by organophosphate insecticides
- VernacularTitle:有机磷农药敌敌畏和对硫磷所致大鼠循环衰竭时的血流动力学特征
- Author:
Nian LIU
;
Jiewei CAO
;
Ruhuan WANG
;
Chaoliang LONG
;
Hai WANG
- Publication Type:Journal Article
- Keywords:
Cholinesterase inhibitors;
Insecticides,organophosphate;
Circulatory failure;
Hemodynamics
- From:
Chinese Journal of Pathophysiology
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the changes of hemodynamic parameters and ECG in circulatory failure rats induced by organophosphate insecticides DDV and parathion.METHODS: Healthy Wistar male rats,weighing(320?20)g,were treated with organophosphate insecticides by ip.to induce circulatory failure.When the mean blood pressure(MBP) decreased to 45 mmHg,the changes of hemodynamic parameters and ECG were observed.RESULTS: In circulatory failure rats,SBP,DBP,MBP,HR,LVDP,IP,+dp/dtmax,-dp/dtmax,Vpm and +dp/dtmax/IP changed dramatically(P
