The Polymorphism of HindⅢ and PvuII Sites in the Lipoprotein Lipase Gene in Patients with Type 2 Diabetes Mellitus and Insulin Resistance
- VernacularTitle:2型糖尿病及胰岛素抵抗与脂蛋白脂酶基因HindⅢ和PvuⅡ酶切位点多态性相关性的研究
- Author:
Xiaodong CUI
;
Miaona JIANG
;
Linxuan SONG
- Publication Type:Journal Article
- Keywords:
Type 2 diabetes mellitus;
Insulin resistance;
Lipoprotein lipase gene;
Restriction fragment length polymorphism
- From:
Chinese Journal of Prevention and Control of Chronic Diseases
2006;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the frequencies of variant of lipoprotein lipase(LPL)gene,HindIII site at intron 8 and PvuII site at intron 6,and its relation with type 2 diabetes mellitus and insulin resistance(IR).Methods PCR-RFLP method was used to determine the DNA polymorphism of 8 th intron and 6 th intron of LPL gene in 78 T2DM patients and 49 controls.Results(1)Compared with control group,the frequencies of H+H+ genotypes and alleles ″H+″ was significantly higher in type 2 diabetes patients(P
