Expression and clinical significance of Bmi-1 in gastric carcinoma
- VernacularTitle:胃癌患者预后及病理因素与Bmi-1表达的相关性研究
- Author:
Jianhua LIU
;
Kaihong HUANG
;
Xuexian LI
;
Libing SONG
;
Baohong GUO
;
Yan FENG
;
Musheng ZENG
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
Bmi-1;
Neoplasm invasiveness;
Prognosis
- From:
Chinese Journal of Pathophysiology
2000;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the relationship between expression of Bmi-1(B cell-specific MLV integration site-1) in gastric cancer and its clinicopathologic significance.METHODS: 146 surgical patients with gastric carcinoma were followed up at least 2 years.Expression of Bmi-1 protein was examined by immunohistochemistry in their archival paraffin embedded tissue specimens.RESULTS: The intensive positive rate of Bmi-1 expression in gastric cancer was 67.8%(99/146).Expression of Bmi-1 was highly correlated with tumor size,clinical stage,lymph node metastasis and T classification(P0.05).The survival rate in the patients with Bmi-1 expression was much lower than that in those patients without Bmi-1 expression(P
