Effects of Sodium Ferulate on Vascular Endothelial Growth Factor and Tumor Necrosis Factor- ? in Patients with Rheumatoid Arthritis
- VernacularTitle:阿魏酸钠对类风湿关节炎患者血清VEGF和TNF-?表达的影响
- Author:
Fang LI
;
Yiqing TIAN
;
Fengxiao ZHANG
;
Lijun SUN
;
Jiemei TAO
- Publication Type:Journal Article
- Keywords:
Rheumatoid arthritis;
Vascular endothelial growth factor;
Tumor necrosis factor- ?;
Sodium ferulate
- From:
China Pharmacy
2005;0(23):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To study the curative effect of Sodium Ferulate( SF) on rheumatoid arthritis( RA) and its effects on the levels of serum vascular endothelial growth factor( VEGF) and tumor necrosis factor- ? ( TNF- ? ) . METHODS: A total of 43 patients with RA were randomly divided into trial group and the control group: conventional treatment was adopted in both groups, but the trial group was treated additionally with SF injection for 4 consecutive weeks. Serum levels of VEGF and TNF- ? before and after treatment were determined by the enzyme linked immunosorbent assay( ELISA) . RESULTS: The total effective rate in the trial group the control group were 91. 30% vs. 75. 00% ( P
