Effect of microcapsulated catechin on expression of vascular endothelial growth factor in rats with adriamycin induced-nephrotic syndrome
- VernacularTitle:微胶囊化儿茶素对阿霉素肾病大鼠VEGF表达的影响
- Author:
Xiaojie HE
;
Zhuwen YI
;
Huabin YANG
;
Haitao BAI
;
Shuanghong MO
;
Xiqiang DANG
- Publication Type:Journal Article
- Keywords:
Catechin;
Nephrotic syndrome;
Endothelial growth factors;
Rats
- From:
Chinese Journal of Pathophysiology
2000;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the effect of microcapsulated catechin on vascular endothelial grower factor(VEGF) expression in rats with adriamycin induced-nephrotic syndrome.METHODS: 120 female SD rats were randomly distributed in control group,nephrotic group,dexamethason group,vitamin E group,catechin group and microcapsule group.Rat with nephrotic syndrome were induced by injection of adriblastine(5 mg/kg BW).VEGF concentrations in serum and urine were detected by ELISA assay.VEGF expression in kidney was measured by immunohistochemistry assay.RESULTS: At the end of 4th week and 6th week,VEGF concentration in other groups in kidney,serum and urine were higher than that in control(all P
