Reduced Glutathione for Alcoholic Liver Disease:Observation of Curative Efficacy
- VernacularTitle:还原型谷胱甘肽治疗酒精性肝病疗效观察
- Author:
Yi LIU
;
Dazhi ZHANG
;
Weiqun ZENG
;
Xiaofeng SHI
;
Zhiyi WANG
;
Hua HE
;
Zhi ZHOU
;
Yourong ZHAO
- Publication Type:Journal Article
- Keywords:
Reduced glutathione;
Alcoholic liver disease;
Comparison of curative efficacy
- From:
China Pharmacy
2005;0(17):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To evaluate the curative effect and safety of reduced glutathione for injection(Atomolan) on the Alcoholic Liver Disease(ALD).METHODS:This was a randomized,placebo controlled study,in which the reduced glutathione for injection(Gluthion) was used as control substance.A total of 261 ALD patients were randomly divided into 2 groups in 1:1 ratio(trial group,n=135;control group,n=126).The dosage,route and course of treatment in two groups were the same.Clinical data including biochemical parameters,symptoms and signs in two groups were monitored.RESULTS:The excellent effective rate,effect rate and total effective rate in the trial group were 58.5%,23.7% and 82.2%,respectively,those in the control group were 57.9%,22.2% and 80.2%,respectively,showing no significant difference between the 2 groups(P=0.90).CONC-LUSION:The study showed that the domestic glutathione for injection had a sound efficacy in improving clinical symptoms and recovery of liver biochemical parameters,showing equivalent efficacy to the control preparation good safety.
