Reduction of Streptomycin Ototoxicity by Tetramethylpyrazine and its Ionic Channel Mechanism
- VernacularTitle:川芎嗪拮抗链霉素耳毒性作用及其离子通道机制
- Author:
Guiying CUI
;
Lijuan SHI
;
Hao TANG
- Publication Type:Journal Article
- Keywords:
Tetramethylpyrazine(TMP);
Outer hair cells;
Streptomycin;
K~+ channel
- From:
Journal of Audiology and Speech Pathology
1998;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of tetraethylplyrazine(TMP) on outward K~+ channel of outer hair cells in guinea pig cochlea.Methods 60 guinea pigs were divided into 6 groups randomly in the experiment.Auditory brainstem response was used to monitor the change of ABR thresholds and patch clamp techniques to observe the effect of TMP on outward K~+ channel.Results TMP decreased the elevated ABR threshold caused by streptomycin. The TMP increased the amplitudes of calcium sensitive potassium channels (I_ K(Ca) ) and delayed outward potassium channels (IK) of outer hair cells of guinea pig cochlea.Conclusion The study indicates that TMP may act as a protective agent against ototoxicity of streptomycin. The amplitudes of I_ K(Ca) and IK of outer hair cells are increased by the TMP,suggesting the possible mechanisms of reducing ototoxicity.
