H-FABP in the Early Diagnosis of Acute Myocardial Infarction
- VernacularTitle:心肌型脂肪酸结合蛋白在早期心肌梗死诊断中的作用
- Author:
Dongbo DENG
;
Qixian WANG
;
Qin FANG
;
Guofan CHEN
;
He CHEN
;
Yanxia ZHU
- Publication Type:Journal Article
- Keywords:
Heart-type fatty acid-binding protein;
Cardiac troponin I;
Creatine kinase-MB;
Myocardial infarction
- From:
Journal of Kunming Medical University
2006;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the diagnostic value of H-FABP、cTnI and CK-MB for early detection of acute myocardial infarction(AMI).Methods 20 New-Zealand rabbits were randomly divided into 2 groups:surgery group(MI group,n=12) and sham surgery group(control group,n=8).MI group was opened the chests and the anterior descending branches of the left coronary arteries(LAD) were ligated;in sham surgery group the sutures were passed under the LADs without ligation.Blood sampled before surgery and 1,2,3,4,6,8,10 and 24 h after surgery.H-FABP,cTnI and CK-MB were measured by ELISA respectively at the same time.Results The plasma concentrations of H-FABP 1 hour after surgery showed statistical difference between MI group and sham surgery group(P
