Expression of muclear factor-kappa B in hepatocellular carcinoma tissue and its significance
- VernacularTitle:NF-?B在肝细胞癌组织中的表达及意义
- Author:
Shuai LIANG
;
Zhiming WANG
;
Xinsheng LU
;
Jingdong LI
;
Ledu ZHOU
;
Xinying LI
- Publication Type:Journal Article
- Keywords:
Nuclear Factor-kappa B;
Carcinoma,Hepalicullar/pathol;
Gene Expression
- From:
Chinese Journal of General Surgery
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the gene expression of nuclear factor-kappa B(NF-?B) and its (biological) significance in liver cancer tissue.Methods The samples from hepatic cancer tissue and(corresponding) adjacent tissues were collected in thirty-two patients with primary liver cancer.The mRNA and protein levels of NF-?B were determined by reverse-transcription PCR and Western bolt,respectively.(Immunochemistry) was employed to determine the localization of NF-?B protein in liver tissues.Results As shown by RT-PCR and Western blot,both mRNA and protein expressions of NF-?B in liver cancer tissues were significantly higher than those in corresponding adjacent liver tissues(P
