Effects of chronic EECP on protein expression in thoracic aorta endothelial cells in porcine with hypercholesteremia
- VernacularTitle:慢性增强型体外反搏对高胆固醇血症猪胸主动脉内皮细胞蛋白质表达的影响
- Author:
Xiaolin CHEN
;
Xiaohong HE
;
Yan ZHANG
;
Yuetao QIAN
;
Luguang LIANG
;
Dianqiu FANG
;
Dengyang ZHAN
;
Zhensheng ZHENG
;
Hong MA
;
Kuijian WANG
- Publication Type:Journal Article
- Keywords:
Counterpulsation;
Hypercholesterolemia;
Endothelial cells;
Proteome
- From:
Chinese Journal of Pathophysiology
2000;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To explore the effect of chronic enhanced external counterpulsation(EECP) on the protein expression in thoracic aorta endothelial cells in porcine with hypercholesteremia by proteomic techniques.METHODS: After performed EECP for 36 h on the hypercholesteremia porcines,the endothelial cells(ECs) were collected from the thoracic aorta and analyzed with proteomic techniques.RESULTS: Six kinds of protein were detected in ECs in the EECP group,but not in the hypercholesteremia control group.CONCLUSION: Chronic EECP may protect ECs against damage resulted from hypercholesteremia by regulating protein expression in artery ECs,subsequently improving cell adhesion and intracellular lipid metabolism and reducing ECs apoptosis.
