Complexation of Clonazepam with Hydroxypropyl-?-cyclodextrin
- VernacularTitle:羟丙基-?-环糊精对氯硝西泮包合作用的研究
- Author:
Rui LI
;
Qunwei XU
;
Jing ZHANG
- Publication Type:Journal Article
- Keywords:
Clonazepam;
Hydroxypropyl-?-cyclodextrin;
Solubility;
Inclusion complex
- From:
China Pharmacy
2005;0(15):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the complexation of clonazepam with hydroxypropyl-?-cyclodextrin(HP-?-CD)in aqueous solutions.METHODS:The complexation of clonazepam with(HP-?-CD),the inclusion molar ratio of host and guest molecules and thermodynamic parameters were detected using phase solubility method,equimolar series method,UV absorption spectroscopy etc.RESULTS:The solubility of clonazepam increased linearly with the increase of(HP-?-CD)level in aqueous solutions at different temperatures(25℃,35℃and45℃)and in buffers at different pH values(4.0,6.0and7.0),the phase solubility diagram was classified as type AL.CONCLUSIONS:Under the above research condition,the incl_ usion complexes of clonazepam with(HP-?-CD)can be formed spontaneously at a molar ratio of1∶1.
