The Changes of Insulin Resistance and ?-cell Function in Patients with Type 2 Diabetes Mellitus after being Treated with the Combination of Glipizide-XL and Glucophage
- VernacularTitle:瑞易宁与格华止联合治疗2型糖尿病及其对自身胰岛?细胞功能及胰岛素抵抗的影响
- Author:
Zhenghua XIAO
;
Dingyu CHEN
;
Zheng ZHOU
- Publication Type:Journal Article
- Keywords:
Glipizide-XL;
Glucophage;
Insulin resistance;
Insulin secretion
- From:
Chinese Journal of Prevention and Control of Chronic Diseases
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate whether the combination of glipizide-XL with glucophage was more rational in insulin resistance and insulin secretion in patients with type 2 diabetes mellitus(T2DM).Methods The changes of insulin resistance and insulin secretion were evaluated from variations of IAI(insulin sensitivity index),IR(insulin resistance index.),IS(insulin secretion index)and HBCI(B-ce1l function index)in cases treated with glipigide-XL and glucophage or either for 18 weeks.Results IAI\IR standing for insulin resistance were higher significantly,and IS & HBCI standing for insulin secretion were lower significantly in patients with T2DM than in normal group(P
