Optimization of Formula and Preparation Technics of Gatifloxacin Dispersible Tablets
- VernacularTitle:加替沙星分散片处方及制备工艺研究
- Author:
Dunwu YAO
- Publication Type:Journal Article
- Keywords:
Gatifloxacin;
Dispersible tablets;
Formula;
Preparation technics
- From:
China Pharmacy
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To optimize the preparation technics and the formula of gatifloxacin dispersible tablets.METHODS:The adjuvant like disintegrant etc.,the formula and preparation process were optimized by a series of experi-ments.The dissolution rates of the principal agent in dispersible tablet and conventional tablet were determined and compared.RESULTS:Sodium carboxymethyl starch and crospolyvinylpyrrolidone were optimized as the disintegrants of the dispersible tablet formula;The dissolution rate of the dispersible tablet was faster than that of the conventional tablet.CONCLUSIONS:The prepared gatifloxacin dispersible tablet is reasonable in formula,feasible in technology and it meets the quality standards.
