A Case of Large Cell Lung Carcinoma with Rhabdoid Phenotype Presenting as Cutaneous Metastasis.
- Author:
Hyun Min SEO
1
;
Jung In KIM
;
Yoon Hwan KIM
;
Joon Hong MIN
;
Seung Jae LEE
;
Ji Hye PARK
;
Won Serk KIM
;
Ga Young LEE
Author Information
1. Department of Dermatology, Sungkyunkwan University School of Medicine, Kangbuk Samsung Hospital, Seoul, Korea. gylee0716@hanmail.net
- Publication Type:Case Report
- Keywords:
Cutaneous metastasis;
Large cell lung carcinoma with rhabdoid phenotype;
Rhabdoid tumor
- MeSH:
Biopsy;
Carcinoma, Large Cell;
Cytoplasm;
Dermis;
Humans;
Lung*;
Middle Aged;
Mucin-1;
Neoplasm Metastasis*;
Phenotype*;
Rhabdoid Tumor;
Scalp;
Skin;
Thyroid Gland;
Vimentin
- From:Korean Journal of Dermatology
2014;52(4):269-273
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Large cell carcinoma with a rhabdoid phenotype is very rare. We report the case of a 53-year-old man who presented with multiple nodules on the scalp, face, and trunk. A skin biopsy revealed large cell carcinoma with a rhabdoid phenotype throughout the dermis. Tumor cells had abundant cytoplasm, eccentric nuclei, and prominent nucleoli and did not adhere to each other. Immunohistochemical tests showed positive reactions for vimentin, epithelial membrane antigen (EMA), and thyroid transcription factor-1 (TTF-1) and weakly focal reactions for pan-CK, CK7, and p63. Imaging studies and a percutaneous lung biopsy were performed and the results were consistent with a large cell lung carcinoma with a rhabdoid phenotype. Based on these clinical and histopathological findings, we concluded that his condition was a cutaneous metastasis from a large cell lung carcinoma with a rhabdoid phenotype, which occurs very rarely.
