A study on the clinicopathological features and prognosis of solid-pseudopapillary tumor of the pancreas
- VernacularTitle:胰腺实性假乳头状瘤临床病理特征及预后的研究
- Author:
Weixia ZHONG
;
Huazhu SONG
;
Lingling GUO
;
Dianbin MU
;
Lanping SUN
;
Aiqing YANG
;
Xuemei ZHAN
;
Yuhui LI
;
Sheng LI
- Publication Type:Journal Article
- Keywords:
Pancreatic neoplasms;
Pathology,clinical;
Diagnosis;
Prognosis;
Sex hormone recepters
- From:
Chinese Journal of General Surgery
1997;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the clinicopathological and immunohistochemical features, histogenesis and biological behavior of solid pseudopapillary tumor of the pancreas ( SPT ). Methods Routine HE and immunohistochemical ( SP) methods were used in 20 cases of SPT. Results There were 18 females and 2 males, age ranging from 13 to 48 years with mean age of 25. 3 years. Abdominal pain and palpable mass were among the main complains. Seventeen cases were followed-up from 9 to 120 monthes. Fourteen cases were alive. Tumors were encapsulated, mixed with solid and cystic tissues. Histological features were psudopapillary structure with a fibrovascular core. Immunohistogically, the tumors were positive for a-1-AT ( 17 cases) , vimentin ( 14 cases) , synaptophysin ( 10 cases) , CgA (5 cases) ,CK and insulin (2 cases) ,glucagon and S-100 (1 case) ,PR (14 cases) , ER (1 case) ,pS2 (6 cases) , but all were negative for CEA and gastrin. Conclusion SPT is of low-graded malignancy and a distinct clinicopathologic entity in young female patients with both exocrine as well as endocrine differentiation. The tumor is closely related with sex hormone receptors.
