Determination of Organic Solvent Residual Volume in Fusidic Acid by Headspace Gas Chromatography
- VernacularTitle:顶空气相色谱法测定夫西地酸中有机溶剂残留量
- Author:
Chengzhang LUAN
;
Bo ZHU
;
Zunwen WANG
;
Liang WANG
- Publication Type:Journal Article
- Keywords:
Fusidic acid;
Headspace gas chromatography;
Organic solvent;
Residual volume
- From:
China Pharmacy
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To determine organic solvent residual volume in fusidic acid by headspace gas chromatography.METHODS:The determination was performed on polyoxyl20000DM-WAX capillary,the column was subjected to tempera-ture programming,the detector temperature was250℃,the carrier gas was helium,the flow rate was7ml/min and the split ratio was1∶1.RESULTS:The linear detective concentration ranges of acetone,methanol and ethanol were2.04～102.50?g/ml(r=0.9992),2.00～99.98?g/ml(r=0.9995)and2.04～102.34?g/ml(r=0.9995),respectively,their average recovery rates were98.7%,99.2%and101.7%,respectively with RSD at2.11%,1.98%and2.01%,respectively.CONCLUSIONS:The method is simple,accurate,and suitable for the determination of organic solvent residual volume in fusidic acid.
