The effect of ectopic accumulation of lipid in the pharyngeal tissue and leptin on the pathogenesis of OSAHS
- VernacularTitle:腭咽组织脂质异位积累及瘦素的检测
- Author:
Rongrong LIU
;
Changyou JI
- Publication Type:Journal Article
- Keywords:
Sleep Apnea Syndromes;
Lipids;
Leptin
- From:
Chinese Archives of Otolaryngology-Head and Neck Surgery
2006;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
0.05). ③All of the OSAHS patients suffered seri-ous lipid metabolic disorders. CONCLUSION ① Fatty infiltration in the pharyngeal tissue may lead to collapse of the pharyngeal airway during sleep. ②The epithelial cells of mucosa,endothelial cells of small vessels and glandular cells of minor salivary glands can potentially produce leptin. Leptin existing with Ob-Rb shows the peripheral action of leptin. The positive ex-pression of leptin and Ob-Rb had no significant differ-ence between the two groups, which may explain theectopic accumulation of lipid. ③ Disordered lipid me-tabolism may not be the determinant factor in the patho-genesis of OSAHS. ④ Endogenous hyperleptinemia may be the protective response to respiratory distur-bance and disordered lipid metabolism, and is also as-sociated with the continuous hypersympathetic activity. The level of leptin in plasma has a positive correlation with the severity of OSAHS.
