Study on the Application of Naloxone Hydrochloride in the Treatment of Acute Craniocerebral Trauma
- VernacularTitle:盐酸纳洛酮在急性重型颅脑损伤治疗中的应用研究
- Author:
Baomin WANG
;
Xizhu WANG
;
Yanling HU
;
Wenjian SHI
;
Litan LIU
;
Ru ZHANG
- Publication Type:Journal Article
- Keywords:
Naloxone hydrochloride;
Craniocerebral trauma;
Endogenous opioid peptides
- From:
China Pharmacy
1991;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To assess the application value of large dose of naloxone hydrochloride in treating early stage craniocerebral trauma.METHODS:79craniocerebral trauma cases whose GCS scores were5to8scores were enrolled:38(control group)were randomly assigned to receive conventional therapy(dehydrating agent,glucocorticoid,antibacterials,nu?tritional brain cells,and so on),and41(naloxone group)to receive additional naloxone besides the conventional therapy as stated in the control group.Variations on GCS scores,serum?-endorphin(?-EP)level,indexes of respiration and circulation,and safe consciousness time of the2groups after treatment were observed.RESULTS:As compared with the control group,naloxone group had shorter safe consciousness time,lower incidences of respiration failure and circulatory failure,more and faster decrease of serum?-EP level(P
