Expression of transcription factor GATA-3 gene in bone marrow stromal cells from patients with aplastic anemia and normal controls
- VernacularTitle:免疫相关转录因子GATA-3基因在再障和正常骨髓基质细胞中的表达
- Author:
Xiuli WU
;
Yangqiu LI
;
Zhen WANG
;
Shaohua CHEN
;
Lijian YANG
;
Yuan ZHANG
;
Kanger ZHU
;
Zhongchao HAN
- Publication Type:Journal Article
- Keywords:
Transcription factors;
Gene expression;
Stromal cells;
Bone marrow;
Anemia, aplastic
- From:
Chinese Journal of Pathophysiology
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the expression of transcription factor GATA-3 gene in the bone marrow stromal cells (BMSCs) from patients with aplastic anemia (AA) and normal controls. METHODS: The expression of GATA-3 gene was analyzed by using RT-PCR-ELISA in BMSCs from 34 normal cases and 9 cases with AA. The standardized semi-quantitative expression level of GATA-3 gene in BMSCs from patients with AA was compared with normal controls. RESULTS: The expression of GATA-3 gene was detected in BMSCs from both normal controls and the cases with AA. The expression level of GATA-3 gene in BMSCs from AA was significant higher than that from the normal controls (P
