Effect of BCPT on Expression of Hippocampus and Cortex MR,GR mRNA in CUS Rats
- VernacularTitle:拟青霉代谢物提取物对慢性应激抑郁模型大鼠皮质激素受体mRNA表达的影响
- Author:
Hongwei KAN
;
Liang MING
;
Lifang ZHENG
;
Yanyan YIN
- Publication Type:Journal Article
- Keywords:
Chronic stress;
Glucocorticoid receptor;
Mineralocorticoid receptor;
mRNA;
Expression
- From:
China Pharmacy
1991;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the antidepressant effects of bioactive compounds from paecilomyces tenuipes(BCPT)on expression of hippocampus and cortex mineralocorticoid receptor(MR),glucocorticoid receptor(GR)mRNA in CUS(chronic unpredictable stress)rats.METHODS:The depression model rat was produced by CUS,the therapy effect of BCPT was observed in CUS rats.It detected expression of hippocampus and cortex MR,GR mRNA with RT-PCR in CUS rats.RESULTS:BCPT could enhance the expression of hippocampus and cortex MR,GR mRNA or decrease the ratio of MR/GR mRNA in CUS rats.CONCLUSION:BCPT could obviously enhance the expression of hippocampus and cortex MR,GR mRNA or decrease the ratio of MR/GR mRNA in CUS rats,the result of this study suggested that BCPT possess certain antidepressant effect.
