Study on Pharmacokinetics and Pharmacodynamics of Single-dose Intramuscularly Injected Methotrexate in the Treatment of Ectopic Pregnancy
- VernacularTitle:单剂量肌肉注射氨甲蝶呤治疗异位妊娠的药动学及药效学研究
- Author:
Jianjian LIANG
;
Juan WANG
;
Jun LU
- Publication Type:Journal Article
- Keywords:
Methotrexate;
Ectopic pregnancy;
Pharmacokinetics;
Pharmacodynamics
- From:
China Pharmacy
2005;0(22):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the pharmacokinetics and pharmacodynamics of single dose of intramuscularly injected methotrexate(MTX)in the treatment of ectopic pregnancy so as to provide theoretical bases for the choice dosage regimen.METHODS:Serum concentration of MTX in 8 cases with ectopic pregnancy were determined by fluorescence polarization immunoassay after injected i.m with single dose MTX(50mg/m2);The ?-HCG was monitored both before and after treatment and the lump sizes of the ectopic pregnancy were determined by B ultrasound.RESULTS:The pharmacokinetics of single dose of intramuscularly injected MTX conformed to two-compartment open model;Cmax occurred at 1.9h after drug taking with 2.31 ?mol/L;The time for the recovery of ?-HCG to normal was(24.8?10)days,the patency rate of oviducts of those who demanding procreation was 75%.CONCLUSION:Injection intramuscularly with single dose of MTX 50mg/m2 is effective in the treatment of ectopic pregnancy.
