Protective effect of octreotide combined with ulinastation on lung injury of acute pancreatitis in rats
- VernacularTitle:善宁联合乌司他丁对大鼠重症急性胰腺炎肺损伤的保护作用
- Author:
Keli TANG
;
Xiongying MIAO
;
Qiang YIN
- Publication Type:Journal Article
- Keywords:
Pancreatitis/compl;
Pancreatitis/drug ther;
Drug Therapy,Combination;
Lung Diseases/etiol;
Octreotide/ther use;
Ulinastation/ther use;
Disrase Models,Animal
- From:
Chinese Journal of General Surgery
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the pathogentic factor of severe acute pancreatitis(SAP)-associated lung injury and the protective function of octreotide combined with alinastatin on SAP-associated lung injury in rats.Methods Eighty SD rats were randomly divided into 5 groups.Sham operative(S)group,SAP group,(octreotide)(O)group,ulinastatin(U)group and octreotide + ulinastatin (O+U)group,and each group was divided into 6h,12h sub-groups.After AP models were induced,the serum concentration of amylase(AMY),tumor necrosis factor?(TNF-?),malondiadehyde(MDA),and the concentration of(myeloperoxidase)(MPO) in lung tissue were determined;and the pancreas and lung pathology were graded,the changes of the above-mentioned indexes after using octreotide and ulinastatin were compared.Results(1)Compared to SAP group,AMY,TNF-?,MDA,MPO,and pancreas pathology score were decreased significantly in each of the 3 therapy groups during the same period;and at 12h,in O+U sub-group,lung pathology score also decreased compared to SAP group(P
