Study on Base Material Optimization of Oxaprozin Gel
- VernacularTitle:奥沙普秦凝胶基质的筛选研究
- Author:
Hong GUO
;
Zhidong LIU
;
Xinggang YANG
;
Weisan PAN
- Publication Type:Journal Article
- Keywords:
Oxaprozin;
Gels;
Permeability coefficient;
Transdermal absorption
- From:
China Pharmacy
2005;0(21):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To observe the effects of different types of carbomers on percutaneous permeability of oxaprozin gels in vitro and to opitmize the formulation of oxaprozin gel. METHODS: The permeability test in vitro was carried out by using Franz diffusion cell with rats' ex vivo skin as barrier. RESULTS: The ex vivo permeability of oxaprozin gel was the best when the carbomer 940 used as its base material with its ex vivo permeability coefficient at 22.77?g/ (cm2?h) . CONCLUSION : The optimized gel base material can act as bases for the production of oxaprozin gel.
