Role of three kinds of potassium channel in airway hyperresponsiveness of asthmatic guinea pigs
- VernacularTitle:3种钾通道在哮喘豚鼠气道高反应中的作用
- Author:
Shiwei DENG
;
Hong YE
;
Si JIN
;
Shiqiao YE
;
Dixun WANG
- Publication Type:Journal Article
- Keywords:
Asthma;
Airway hyperresponsiveness;
Potassium channels, calcium-activated;
Potassium channels, delayed- rectifier;
Potassium channels, ATP sensitive
- From:
Chinese Journal of Pathophysiology
2000;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the role of Ca2+ - activated, delayed - rectifier and ATP sensitive K+ channel (KCa, Kdr, KATP) in airway hyperresponsiveness of asthmatic guinea pigs. METHODS: The method of recording the tone of isolated trachea rings was performed, and the changes of dose-response curves of trachea rings to histamine caused by different K+ channel blockade were investigated. RESULTS: (1) After inhibition of KCa, by tetraethylammonium (TEA) , the dose - response curve of trachea rings to histamine did not change in control group, while the maximal contraction of trachea rings to 10-4 mol/L and 10-3 mol/L histamine decreased significantly ( P
