Study on the Ex Vivo Adsorption of Montmorillonite Powder to Ofloxacin
- VernacularTitle:蒙脱石散对氧氟沙星体外吸附作用研究
- Author:
Jun WU
;
Gang LI
;
Yongzhou YU
;
Jianghong XU
;
Hanyang XIAO
- Publication Type:Journal Article
- Keywords:
Montmorillonite powder;
Ofloxacin;
Adsorption;
Artificial gastric juice;
Artificial intestinal juice
- From:
China Pharmacy
2005;0(19):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the ex vivo adsorption of montmorillonite powder to ofloxacin.METHODS:Different dosages of ofloxacin and montmorillonite powder were mixed with artificial gastric juice and artificial intestinal juice,respec?tively,which were filtrated after warmed at(37?0.5)℃in water bath for1hour,the content changes of ofloxacin were de?termined by ultraviolet spectrometry.RESULTS:The adsorption rates of montmorillonite powder to ofloxacin in artificial gastric juice and in artificial intestinal juice were(99.76?0.01)%and(99.55?0.02)%,respectively.CONCLUSIONS:Montmorillonite powder has strong adsorption to ofloxacin in both artificial gastric juice and artificial intestinal juice,there?fore,which should not be administered simultaneously in the clinic.
